Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner

Wolfs, T., Kallapur, S., Knox, C.L., Thuijls, G., Nitsos, I., Polglase, G., Collins, J., Kroon, E., Spierings, J., Shroyer, N., Newnham, J., Jobe , A., & Kramer, B.W. (2013) Antenatal ureaplasma infection impairs development of the fetal ovine gut in an IL-1-dependent manner. Mucosal Immunology, 6, pp. 547-556.

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Abstract

Ureaplasma infection of the amniotic cavity is associated with adverse postnatal intestinal outcomes. We tested whether interleukin-1 (IL-1) signaling underlies intestinal pathology following ureaplasma exposure in fetal sheep. Pregnant ewes received intra-amniotic injections of ureaplasma or culture media for controls at 3, 7, and 14 d before preterm delivery at 124 d gestation (term 150 d). Intra-amniotic injections of recombinant human interleukin IL-1 receptor antagonist (rhIL-1ra) or saline for controls  were given 3 h before and every 2 d after Ureaplasma injection. Ureaplasma exposure caused fetal gut inflammation within 7 d with damaged villus epithelium and gut barrier loss. Proliferation, differentiation, and maturation of enterocytes were significantly reduced after 7 d of ureaplasma exposure, leading to severe villus atrophy at 14 d. Inflammation, impaired development and villus atrophy of the fetal gut was largely prevented by intra-uterine rhIL-1ra treatment. These data form the basis for a clinical understanding of the role of ureaplasma in postnatal intestinal pathologies.

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ID Code: 55480
Item Type: Journal Article
Refereed: Yes
Keywords: inflammation, epithelial cells, mucosal damage, maturation, fetus, Ureaplasma
DOI: 10.1038/mi.2012.97
ISSN: 1935-3456
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Infectious Diseases (110309)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PAEDIATRICS AND REPRODUCTIVE MEDICINE (111400) > Foetal Development and Medicine (111401)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Society for Mucosal Immunology
Deposited On: 11 Dec 2012 22:42
Last Modified: 02 Jan 2014 21:30

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