Direct fabrication as a patient-targeted therapeutic in a clinical environment

Hutmacher, Dietmar, Woodruff, Maria A., Shakesheff, Kevin, & Guldberg, Robert E. (2012) Direct fabrication as a patient-targeted therapeutic in a clinical environment. Methods in Molecular Biology, 868, pp. 327-340.

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A paradigm shift is taking place in orthopaedic and reconstructive surgery. This transition from using medical devices and tissue grafts towards the utilization of a tissue engineering approach combines biodegradable scaffolds with cells and/or biological molecules in order to repair and/or regenerate tissues. One of the potential benefits offered by solid freeform fabrication (SFF) technologies is the ability to create such biodegradable scaffolds with highly reproducible architecture and compositional variation across the entire scaffold due to their tightly controlled computer-driven fabrication. Many of these biologically activated materials can induce bone formation at ectopic and orthotopic sites, but they have not yet gained widespread use due to several continuing limitations, including poor mechanical properties, difficulties in intraoperative handling, lack of porosity suitable for cellular and vascular infiltration, and suboptimal degradation characteristics. In this chapter, we define scaffold properties and attempt to provide some broad criteria and constraints for scaffold design and fabrication in combination with growth factors for bone engineering applications. Lastly, we comment on the current and future developments in the field, such as the functionalization of novel composite scaffolds with combinations of growth factors designed to promote cell attachment, cell survival, vascular ingrowth, and osteoinduction.

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ID Code: 55499
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1007/978-1-61779-764-4_20
ISSN: 1940-6029 (online) 1064-3745 (print)
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Medical Devices (090304)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 Springer Science+Business Media, LLC
Deposited On: 11 Dec 2012 22:01
Last Modified: 01 Sep 2016 23:42

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