Partitioning of persistent organic pollutants (POPs) between human serum and breast milk : a literature review

Mannetje, Andrea, Coakley, Jonathon, Mueller, Jochen, Harden, Fiona, Toms, Leisa-Maree, & Douwes, Jeromy (2012) Partitioning of persistent organic pollutants (POPs) between human serum and breast milk : a literature review. Chemosphere, 89(8), pp. 911-918.

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Abstract

The literature was reviewed to assess the relationship between the lipid adjusted concentration in human serum and breast milk (expressed as the serum/milk ratio) of a broad range of POPs in paired samples. Thirteen studies were identified, including seven studies that reported serum/milk ratios for polychlorinated dibenzo-dioxins and -furans (PCDD/Fs), ten for polychlorinated biphenyls (PCBs), five for polybrominated diphenyl ethers (PBDEs), and five for organochlorine pesticides (OCPs). Mean serum/milk ratios ranged between 0.7 and 25 depending on the compound and congener. For PCDD/Fs, PCBs and PBDEs, a clear trend of increasing mean serum/milk ratio by increasing molar volume, hydrophobicity and number of halogen substitutes was observed. The mean serum/milk ratios reported by the 13 studies summarized here will aid comparison between human POPs exposure studies using either serum or milk samples. More studies are needed to allow a valid comparison between data obtained from analysis of breast milk and serum samples for a broader range of POPs. Furthermore such studies may shed light on compound specific factors as well as other determinants that may affect the partitioning and partition kinetics of POPs between serum and breast milk.

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ID Code: 55578
Item Type: Journal Article
Refereed: Yes
Keywords: PCDD/Fs; PCBs; PBDEs; Organochlorine pesticides; Human serum; Breast milk
DOI: 10.1016/j.chemosphere.2012.06.049
ISSN: 1879-1298
Subjects: Australian and New Zealand Standard Research Classification > ENVIRONMENTAL SCIENCES (050000) > OTHER ENVIRONMENTAL SCIENCES (059900) > Environmental Sciences not elsewhere classified (059999)
Divisions: Current > Schools > School of Clinical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 12 Dec 2012 04:33
Last Modified: 13 Dec 2012 05:06

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