Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles

Malda, J., Benders, K.E., Klein, T.J., de Grauw, J.C., Kik, M.J., Hutmacher, D.W., Saris, D.B., van Weeren, P.R., & Dhert, W.J. (2012) Comparative study of depth-dependent characteristics of equine and human osteochondral tissue from the medial and lateral femoral condyles. Osteoarthritis and cartilage, 20(10), pp. 1147-1151.

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Articular cartilage defects are common after joint injuries. When left untreated, the biomechanical protective function of cartilage is gradually lost, making the joint more susceptible to further damage, causing progressive loss of joint function and eventually osteoarthritis (OA). In the process of translating promising tissue-engineering cartilage repair approaches from bench to bedside, pre-clinical animal models including mice, rabbits, goats, and horses, are widely used. The equine species is becoming an increasingly popular model for the in vivo evaluation of regenerative orthopaedic approaches. As there is also an increasing body of evidence suggesting that successful lasting tissue reconstruction requires an implant that mimics natural tissue organization, it is imperative that depth-dependent characteristics of equine osteochondral tissue are known, to assess to what extent they resemble those in humans. Therefore, osteochondral cores (4-8 mm) were obtained from the medial and lateral femoral condyles of equine and human donors. Cores were processed for histology and for biochemical quantification of DNA, glycosaminoglycan (GAG) and collagen content. Equine and human osteochondral tissues possess similar geometrical (thickness) and organizational (GAG, collagen and DNA distribution with depth) features. These comparable trends further underscore the validity of the equine model for the evaluation of regenerative approaches for articular cartilage.

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21 citations in Web of Science®

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ID Code: 55588
Item Type: Journal Article
Refereed: Yes
Additional Information: Malda, J
Benders, K E M
Klein, T J
de Grauw, J C
Kik, M J L
Hutmacher, D W
Saris, D B F
van Weeren, P R
Dhert, W J A
Osteoarthritis Cartilage. 2012 Oct;20(10):1147-51. doi: 10.1016/j.joca.2012.06.005. Epub 2012 Jul 7.
DOI: 10.1016/j.joca.2012.06.005
ISSN: 1522-9653
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 12 Dec 2012 22:45
Last Modified: 18 Dec 2012 02:42

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