Neural differentiation of mouse embryonic stem cells on conductive nanofiber scaffolds
Kabiri, Mahboubeh, Soleimani, Masoud, Shabani, Iman, Futrega, Kathryn, Ghaemi, Naser, Ahvaz, Hana Hanaee, Elahi, Elahe, & Doran, Michael (2012) Neural differentiation of mouse embryonic stem cells on conductive nanofiber scaffolds. Biotechnology Letters, 34(7), pp. 1357-1365.
Nerve tissue engineering requires suitable precursor cells as well as the necessary biochemical and physical cues to guide neurite extension and tissue development. An ideal scaffold for neural regeneration would be both fibrous and electrically conductive. We have contrasted the growth and neural differentiation of mouse embryonic stem cells on three different aligned nanofiber scaffolds composed of poly L: -lactic acid supplemented with either single- or multi-walled carbon-nanotubes. The addition of the nanotubes conferred conductivity to the nanofibers and promoted mESC neural differentiation as evidenced by an increased mature neuronal markers expression. We propose that the conductive scaffold could be a useful tool for the generation of neural tissue mimics in vitro and potentially as a scaffold for the repair of neural defects in vivo.
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|Item Type:||Journal Article|
|Keywords:||Electrospun Fibers, Embryonic Stem Cells, Electrical Stimulation, Neural Differentiation|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomedical Engineering not elsewhere classified (090399)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Copyright Owner:||Copyright 2012 Springer Netherlands|
|Copyright Statement:||The original publication is available at www.springerlink.com|
|Deposited On:||14 Dec 2012 01:32|
|Last Modified:||18 Dec 2012 04:03|
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