Lineage-specific biomarkers predict response to FGFR inhibition

Loch, David & Pollock, Pamela M. (2012) Lineage-specific biomarkers predict response to FGFR inhibition. Cancer Discovery, 2, pp. 1081-1083.

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Abstract

In this issue of Cancer Discovery, Guagnano and colleagues use a large and diverse annotated collection of cancer cell lines, the Cancer Cell Line Encyclopedia, to correlate whole-genome expression and genomic alteration datasets with cell line sensitivity data to the novel pan-fibroblast growth factor receptor (FGFR) inhibitor NVP-BGJ398. Their findings underscore not only the preclinical use of such cell line panels in identifying predictive biomarkers, but also the emergence of the FGFRs as valid therapeutic targets, across an increasingly broad range of malignancies.

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ID Code: 55957
Item Type: Journal Article
Refereed: No
Keywords: FGFR2, BGJ398, review, FGFR1, FGFR3, FGF19, Klotho
DOI: 10.1158/2159-8290.CD-12-0486
ISSN: 2159-8290
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Molecular Targets (111207)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 American Association for Cancer Research
Deposited On: 20 Dec 2012 05:31
Last Modified: 04 Dec 2013 03:37

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