Comparison of robust criteria for D-optimal design

Foo, Lee Kien, McGree, James, Eccleston, John, & Duffull, Stephen (2012) Comparison of robust criteria for D-optimal design. Journal of Biopharmaceutical Statistics, 22(6), pp. 1193-1205.

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This study compared the performance of a local and three robust optimality criteria in terms of the standard error for a one-parameter and a two-parameter nonlinear model with uncertainty in the parameter values. The designs were also compared in conditions where there was misspecification in the prior parameter distribution. The impact of different correlation between parameters on the optimal design was examined in the two-parameter model. The designs and standard errors were solved analytically whenever possible and numerically otherwise.

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6 citations in Web of Science®

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ID Code: 56074
Item Type: Journal Article
Refereed: Yes
Keywords: D-optimal design, ED-design, Nonlinear model, Pharmacokinetics, Robust design, Standard error
DOI: 10.1080/10543406.2011.580484
ISSN: 1054-3406
Subjects: Australian and New Zealand Standard Research Classification > MATHEMATICAL SCIENCES (010000) > STATISTICS (010400)
Divisions: Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 03 Jan 2013 05:55
Last Modified: 12 Jun 2013 15:25

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