Prenatal Vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation
Fernandes de Abreu, Diana Andrea, Landel, Véréna, Barnett, Adrian G., McGrath, John, Eyles, Darryl, & Feron, Francois (2012) Prenatal Vitamin D deficiency induces an early and more severe experimental autoimmune encephalomyelitis in the second generation. International Journal of Molecular Sciences, 13(12), pp. 10911-10919.
In a previous study, we demonstrated that mouse adult F(1) offspring, exposed to a vitamin d deficiency during pregnancy, developed a less severe and delayed Experimental Autoimmune Encephalomyelitis (EAE), when compared with control offspring. We then wondered whether a similar response was observed in the subsequent generation. To answer this question, we assessed F(2) females whose F(1) parents (males or females) were vitamin d-deprived when developing in the uterus of F(0) females. Unexpectedly, we observed that the vitamin d deficiency affecting the F(0) pregnant mice induced a precocious and more severe EAE in the F(2) generation. This paradoxical finding led us to assess its implications for the epidemiology of Multiple Sclerosis (MS) in humans. Using the REFGENSEP database for MS trios (the patient and his/her parents), we collected the parents' dates of birth and assessed a potential season of birth effect that could potentially be indicative of the vitamin d status of the pregnant grandmothers. A trend for a reduced number of births in the Fall for the parents of MS patients was observed but statistical significance was not reached. Further well powered studies are warranted to validate the latter finding.
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|Item Type:||Journal Article|
|Keywords:||vitamin D, multiple sclerosis, deficiency, season of birth, transgenerational|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)|
|Divisions:||Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
|Copyright Owner:||Copyright 2012 M D P I AG|
|Deposited On:||07 Jan 2013 02:38|
|Last Modified:||09 Jan 2013 05:28|
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