Signal transduction mechanisms underlying growth hormone receptor action

Herington, Adrian & Lobie, Peter (2012) Signal transduction mechanisms underlying growth hormone receptor action. The Open Endocrinology Journal, 6(1), pp. 13-21.

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Our understanding of the mechanisms of action of GH and its receptor, the GHR, has advanced significantly in the last decade and has provided some important surprises. It is now clear that the GH-GHR axis activates a number of inter-related signalling pathways, not all of which are dependent on the intracellular tyrosine kinase, JAK2 as originally postulated. JAK2-independent pathways, mediated via the Src family kinases, together with a number of negative regulators of GH signalling and emerging cross-talk mechanisms with other growth factor receptors, provide a complex array of mechanisms that are capable of fine-tuning responses to GH in a cell context dependent manner. Additionally, it is also now clear that GH and the GHR can translocate to the nucleus of target cells and initiate, as yet not well defined, nuclear responses. Continued emphasis on elucidation of these complex mechanisms is critical to provide further insights into the diverse physiological and pathophysiological effects of GH.

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ID Code: 56344
Item Type: Journal Article
Refereed: Yes
Keywords: Growth hormone receptor, JAK2, Scr kinases, Suppressors of Cytokine Signalling, Nuclear translocation
ISSN: 1874-2165/12
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Herington and Lobie.
Copyright Statement: © Herington and Lobie.; Licensee Bentham Open.
This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (
3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited.
Deposited On: 10 Jan 2013 05:38
Last Modified: 11 Jan 2013 17:39

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