Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation

Cowin, Allison J, Lei, Nazi, Linda, Franken, Ruzehaji, Nadira, Offenhäuser, Carolin, Kopecki, Zlatko, & Murray, Rachael (2012) Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation. Communicative & Integrative Biology, 5(6), pp. 546-549.

View at publisher


Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid.

Impact and interest:

2 citations in Scopus
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

91 since deposited on 11 Jan 2013
9 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 56390
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Tissue Repair, Wound Healing, Inflammation
DOI: 10.4161/cib.21928
ISSN: 1942-0889
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Open access
Copyright Statement: - author can archive post-print (ie final draft post-refereeing)
- subject to Restrictions below, author can archive publisher's version/PDF
•Authors final version only
•On Institutional Repository
•Must link to publisher version
•Published source must be acknowledged
•Landes Bioscience will deposit in PubMed Central or Europe PMC within 6-12 months of publication, depending on funding agency policy
•Embargoes on funding agency requirements, can be removed by payment of Open Access fee
•Publisher's version/PDF may be used upon payment of Open Access fee
Deposited On: 11 Jan 2013 03:40
Last Modified: 23 Jan 2013 09:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page