Elevated uric acid correlates with wound severity

Fernandez, Melissa Laura, Upton, Zee, Edwards, Helen E., Finlayson, Kathleen J., & Shooter, Gary K. (2012) Elevated uric acid correlates with wound severity. International Wound Journal, 9(2), pp. 139-149.

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Abstract

Chronic venous leg ulcers are a major health issue and represent an often overlooked area of biomedical research. Nevertheless, it is becoming increasingly evident that new approaches to enhance healing outcomes may arise through better understanding the processes involved in the formation of chronic wounds. We have for the first time shown that the terminal purine catabolite uric acid (UA) is elevated in wound fluid (WF) from chronic venous leg ulcers with relative concentrations correlating with wound chronicity. We have also shown a corresponding depletion in UA precursors, including adenosine, with increased wound severity. Further, we have shown that xanthine oxidase, the only enzyme in humans that catalyses the production of UA in conjunction with a burst of free radicals, is active in chronic WF. Taken together, this provides compelling evidence that xanthine oxidase may play a critical role in the formation of chronic wounds by prolonging the inflammatory process.

Impact and interest:

12 citations in Scopus
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11 citations in Web of Science®

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ID Code: 56560
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: chronic venous leg ulcers, purines, uric acid, wound fluid and xanthine oxidase
DOI: 10.1111/j.1742-481X.2011.00870.x
ISSN: 1742-481X (online) 1742-4801 (print)
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Copyright Owner: Copyright 2012 The Authors, Blackwell Publishing Ltd and Medicalhelplines.com Inc.
Deposited On: 21 Jan 2013 22:29
Last Modified: 23 Jan 2013 05:34

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