Reduced Il17a expression distinguishes a Ly6cloMHCIIhi macrophage population promoting wound healing

Rodero, Mathieu P., Hodgson, Samantha S., Hollier, Brett G., Combadiere, Christophe, & Khosrotehrani, Kiarash (2012) Reduced Il17a expression distinguishes a Ly6cloMHCIIhi macrophage population promoting wound healing. Journal Of Investigative Dermatology.

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Macrophages are the main components of inflammation during skin wound healing. They are critical in wound closure and in excessive inflammation, resulting in defective healing observed in chronic wounds. Given the heterogeneity of macrophage phenotypes and functions, we here hypothesized that different subpopulations of macrophages would have different and sometimes opposing effects on wound healing. Using multimarker flow cytometry and RNA expression array analyses on macrophage subpopulations from wound granulation tissue, we identified a Ly6cloMHCIIhi “noninflammatory” subset that increased both in absolute number and proportion during normal wound healing and was missing in Ob/Ob and MYD88−/− models of delayed healing. We also identified IL17 as the main cytokine distinguishing this population from proinflammatory macrophages and demonstrated that inhibition of IL17 by blocking Ab or in IL17A−/− mice accelerated normal and delayed healing. These findings dissect the complexity of the role and activity of the macrophages during wound inflammation and may contribute to the development of therapeutic approaches to restore healing in chronic wounds.

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ID Code: 56797
Item Type: Journal Article
Refereed: Yes
Additional Information: Advance online publication 13 December 2012
Keywords: I 17a expression, Ly6clow, MHCIIhi macrophage, wound healing, dermatology
DOI: 10.1038/jid.2012.368
ISSN: 1523-1747
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Dermatology (110304)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Feb 2013 23:42
Last Modified: 16 Sep 2016 03:38

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