Cellular model systems to study the tumor biological role of kallikrein-related peptidases in ovarian and prostate cancer
Dong, Ying, Loessner, Daniela, Sieh, Shirly, Taubenberger, Anna V., Fuhrman-Luck, Ruth, Magdolen, V., Hutmacher, Dietmar, & Clements, Judith (2012) Cellular model systems to study the tumor biological role of kallikrein-related peptidases in ovarian and prostate cancer. In Schmitt, M., Magdoen, V., Somerhoff, C., & Fritz, H. (Eds.) Kallikrein-related peptidases [Volume 2] : Novel cancer-related biomarkers. deGruyter, Berlin, pp. 83-110.
Since the identification of the gene family of kallikrein related peptidases (KLKs), their function has been robustly studied at the biochemical level. In vitro biochemical studies have shown that KLK proteases are involved in a number of extracellular processes that initiate intracellular signaling pathways by hydrolysis, as reviewed in Chapters 8, 9, and 15, Volume 1. These events have been associated with more invasive phenotypes of ovarian, prostate, and other cancers. Concomitantly, aberrant expression of KLKs has been associated with poor prognosis of patients with ovarian and prostate cancer (Borgoño and Diamandis, 2004; Clements et al., 2004; Yousef and Diamandis, 2009), with prostate-specific antigen (PSA, KLK3) being a long standing, clinically employed biomarker for prostate cancer (Lilja et al., 2008). Data generated from patient samples in clinical studies, alongwith biochemical activity, suggests that KLKs function in the development and progression of these diseases. To bridge the gap between their function at the molecular level and the clinical need for efficacious treatment and prognostic biomarkers, functional assessment at the in vitro cellular level, using various culture models, is increasing, particularly in a three-dimensional (3D) context (Abbott, 2003; Bissell and Radisky, 2001; Pampaloni et al., 2007; Yamada and Cukierman, 2007).
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|Item Type:||Book Chapter|
|Keywords:||Cellular model systems, tumour, kalikrein proteases, ovarian cancer, prostate cancer|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)|
|Divisions:||Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
|Deposited On:||07 Feb 2013 05:56|
|Last Modified:||12 Jun 2013 15:29|
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