A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease

Amin Al Olama, A., Kote-Jarai, Z., Schumacher, F.R., Wiklund, F., Berndt, S.I., Benlloch, S., Giles, G.G., Severi, G., Neal, D.E., Hamdy, F.C., Donovan, J.L., Hunter, D.J., Henderson, B.E., Thun, M.J., Gaziano, M., Giovannucci, E.L., Siddiq, A., Travis, R.C., Cox, D.G., Canzian, F., Riboli, E., Key, T.J., Andriole, G., Albanes, D., Hayes, R.B., Schleutker, J., Auvinen, A., Tammela, T.L.J., Weischer, M., Stanford, J.L., Ostrander, E.A., Cybulski, C., Lubinski, J., Thibodeau, S.N., Schaid, D.J., Sorensen, K. D., Batra, J., Clements, J.A., Chambers, S., Aitken, J., Gardiner, R.A., Maier, C., Vogel, W., Dork, T., Brenner, H., Habuchi, T., Ingles, S., John, E.M., Dickinson, J.L., Cannon-Albright, L., Teixeira, M.R., Kaneva, R., Zhang, H.-W., Lu, Y.-J., Park, J.Y., Cooney, K.A., Muir, K.R., Leongamornlert, D.A., Saunders, E., Tymrakiewicz, M., Mahmud, N., Guy, M., Govindasami, K., O'Brien, L.T., Wilkinson, R.A., Hall, A.L., Sawyer, E.J., Dadaev, T., Morrison, J., Dearnaley, D.P., Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Van As, N., Woodhouse, C.J., Thompson, A., Dudderidge, T., Ogden, C., Cooper, C.S., Lophatonanon, A., Southey, M.C., Hopper, J.L., English, D., Virtamo, J., Le Marchand, L., Campa, D., Kaaks, R., Lindstrom, S., Diver, W.R., Gapstur, S., Yeager, M., Cox, A., Stern, M.C., Corral, R., Aly, M., Isaacs, W., Adolfsson, J., Xu, J., Zheng, S.L., Wahlfors, T., Taari, K., Kujala, P., Klarskov, P., Nordestgaard, B.G., Roder, M.A., Frikke-Schmidt, R., Bojesen, S.E., FitzGerald, L.M., Kolb, S., Kwon, E.M., Karyadi, D.M., Orntoft, T.F., Borre, M., Rinckleb, A., Luedeke, M., Herkommer, K., Meyer, A., Serth, J., Marthick, J.R., Patterson, B., Wokolorczyk, D., Spurdle, A., Lose, F., McDonnell, S.K., Joshi, A.D., Shahabi, A., Pinto, P., Santos, J., Ray, A., Sellers, T.A., Lin, H.-Y., Stephenson, R.A., Teerlink, C., Muller, H., Rothenbacher, D., Tsuchiya, N., Narita, S., Cao, G.-W., Slavov, C., Mitev, V., Chanock, S., Gronberg, H., Haiman, C.A., Kraft, P., Easton, D.F., & Eeles, R.A. (2012) A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease. Human Molecular Genetics, 22(2), pp. 408-415.

View at publisher (open access)

Abstract

Genome-wide association studies (GWAS) have identified multiple common genetic variants associated with an increased risk of prostate cancer (PrCa), but these explain less than one-third of the heritability. To identify further susceptibility alleles, we conducted a meta-analysis of four GWAS including 5953 cases of aggressive PrCa and 11 463 controls (men without PrCa). We computed association tests for approximately 2.6 million SNPs and followed up the most significant SNPs by genotyping 49 121 samples in 29 studies through the international PRACTICAL and BPC3 consortia. We not only confirmed the association of a PrCa susceptibility locus, rs11672691 on chromosome 19, but also showed an association with aggressive PrCa [odds ratio = 1.12 (95% confidence interval 1.03-1.21), P = 1.4 × 10(-8)]. This report describes a genetic variant which is associated with aggressive PrCa, which is a type of PrCa associated with a poorer prognosis.

Impact and interest:

57 citations in Scopus
15 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 56933
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
Keywords: Meta-analysis, Genome , prostate cancer, susceptibility, aggressive and non-aggressive
DOI: 10.1093/hmg/dds425
ISSN: 1460-2083
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 07 Feb 2013 04:49
Last Modified: 17 Jul 2017 17:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page