Identification of evidence-based biospecimen quality-control tools

Betsou, Fotini, Gunter, Elaine, Clements, Judith, DeSouza, Yvonne, Goddard, Katrina A.B., Guadagni, Fiorella, Yan, Wusheng, Skubitz, Amy, Somiari, Stella, Yeadon, Trina, & Chuaqui, Rodrigo (2013) Identification of evidence-based biospecimen quality-control tools. The Journal of Molecular Diagnostics, 15(1), pp. 3-16.

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Control of biospecimen quality that is linked to processing is one of the goals of biospecimen science. Consensus is lacking, however, regarding optimal sample quality-control (QC) tools (ie, markers and assays). The aim of this review was to identify QC tools, both for fluid and solid-tissue samples, based on a comprehensive and critical literature review. The most readily applicable tools are those with a known threshold for the preanalytical variation and a known reference range for the QC analyte. Only a few meaningful markers were identified that meet these criteria, such as CD40L for assessing serum exposure at high temperatures and VEGF for assessing serum freeze-thawing. To fully assess biospecimen quality, multiple QC markers are needed. Here we present the most promising biospecimen QC tools that were identified.

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32 citations in Scopus
23 citations in Web of Science®
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ID Code: 56936
Item Type: Journal Article
Refereed: Yes
Keywords: biospecimen, control tools
DOI: 10.1016/j.jmoldx.2012.06.008
ISSN: 1525-1578
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Genetics (111203)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 07 Feb 2013 02:37
Last Modified: 12 Jun 2013 15:30

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