Aqueous PEG-HEMA hydrogel synthesis using gamma irradiation for wound dressing applications
Rayment, Erin A. & George, Graeme A. (2005) Aqueous PEG-HEMA hydrogel synthesis using gamma irradiation for wound dressing applications. In Tissue Engineering Society International Conference, Shanghai, China.
Chronic wounds are an important medical issue. Current wound dressings do not fully address all of the relevant issues as many are primarily antimicrobials, which do not attend to potential growth factor deficiencies. In contrast, there are several types of interactive dressings, which claim to maintain a moist wound environment and interact with cells and matrix proteins in the wound. Synthetic scaffolds are advantageous over these animal- and plant-derived products as they are well-defined and completely pathogen-free. The ideal candidate for a wound dressing is the hydrogel. Hydrogel copolymers of PEG and 2-hydroxylethyl methacrylate (HEMA) have earlier been investigated for use as a hydrogel for protein release.
Aqueous solutions of distilled 2-hydroxylethyl methacrylate (HEMA) (Sigma-Aldrich, Australia) and poly(ethylene glycol) (PEG 10,000 and PEG 20,000) (Sigma-Aldrich, Australia) were prepared in two separate ratios [(50% water, 30% PEG and 20% HEMA) and (50% water, 40% PEG and 10% HEMA)]. They were purged with argon and irradiated by a 60Co source at a total dose of 5 KGy, 10 KGy, and 20 KGy respectively, then analysed by a Perkin Elmer System 2000 NIR FT-Raman. Small samples of copolymers were also immersed in water.
FT-Raman spectroscopy results showed that low doses of irradiation allowed complete conversion from the HEMA monomer to its polymer form, shown through the disappearance of the C=C peak at 1639 cm-1.
Five of the copolymers were selected and water uptake tests were performed. Results showed that selected copolymers could swell to over 300% of their original weight with water, with the volume changes being over 450% in optimal combinations.
This method of aqueous PEG-co-HEMA hydrogel synthesis appears to be promising for the generation of wound dressings. A complete conversion of the HEMA monomer can be easily obtained and the resulting copolymers appear cool and flexible to touch.
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|Item Type:||Conference Item (Poster)|
|Additional Information:||For more information please contact the author: firstname.lastname@example.org|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Dermatology (110304)|
|Divisions:||Past > QUT Faculties & Divisions > Faculty of Science and Technology|
|Copyright Owner:||Copyright 2005 (please consult author)|
|Deposited On:||01 Dec 2006|
|Last Modified:||15 Jan 2009 07:16|
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