Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping

Eeles, R.A., Al Olama , A.A., Benlloch, S., Saunders, E.J., Leongamornlert, D.A., Tymrakiewicz , M., Ghoussaini , M., Luccarini, C., Dennis, J., Jugurnauth-Little, S., Dadaev, T., Neal, D.E., Hamdy, F.C., Donovan, J.L., Muir, K., Giles, G.G., Severi, G., Wiklund, F., Gronberg, H., Haiman , C.A., Schumacher, F., Henderson , B.E., Marchand, L.L, Lindstrom, S., Kraft, P., Hunter, D.J., Gapstur, S., Chanock, S., Berndt, S.I., Albanes, D., Andriole, G., Schleutker, J., Weischer, M., Canzian, F., Riboli, A., Key, T.J., Travis, R.C., Campa, D., Ingles, S.A., John, E.M., Hayes, R.B., Pharoah, P., Pashayan, N., Khaw, K-T., Stanford, J.L., Ostrander, E.A., Signorello, L.B., Thibodeau, S.N., Schaid, D., Maier, C., Vogel, W., Kibel, S.A., Cybulski, C., Lubinski, J., Cannon-Albright, L., Brenner, H., Park, J.Y., Kaneva, R., Batra, J., Spurdle, A., Clements, J., Teixeira, M.R., Dicks, E., Lee, A., Dunning, A., Baynes, C., Conroy, D., Maranian, M.J, Ahmed, S., Govindasami, K., Guy, M., Wilkinson, R.A., Sawyer, E.J., Morgan, A., Dearnaley, D.P., Horwich, A., Huddart, R.A., Khoo, V.S., Parker, C.C., Van As, N., Woodhouse, C.J., Thompson, A., Dudderidge, T., Ogden, C., Cooper, C.S., Lophatananon, A., Cox, A., Southey, M.C., Hopper, J.L., English, D.R., Aly, M., Adolfsson, J., Xu, J., Zheng, S.L., Yeager, M., Kaaks, R., Diver, W.R., Gaudet, M., Stern, A., Corral, R., Joshi, A.D., Shahabi, A., Wahlfors, T., Tammela, T.L.J., Auvinen, A., Virtamo, J., Klarskov, P., Nordestgaard, B.G., Roder, M.A., Nielsen, S.F., Bojesen, S.E., Siddiq, A., FitzGerald, L.M., Kolb, S., Kwon, E.M., Karyadi, D.M., Blot, W.J., Zheng, W., Cai, Q., McDonnell, S.K., Rinckleb, A., Drake, B., Colditz, G., Wokolorczyk, D., Stephenson, R.A., Teerlink, C., Muller, H., Rothenbacher, D., Sellers, T.A., Lin, H-Y., Slavov, C., Mitev, V., Lose, F., Srinivasan, S., Maia, S., Paulo, P., Lange, E., Cooney, K.A., Vincent, D., Bacot, F., Tessier, D.C., Kote-Jarai, Z., & Easton, D.F. (2012) Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping. Nature Genetics, 45(4), pp. 385-391.

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Abstract

Prostate cancer is the most frequently diagnosed cancer in males in developed countries. To identify common prostate cancer susceptibility alleles, we genotyped 211,155 SNPs on a custom Illumina array (iCOGS) in blood DNA from 25,074 prostate cancer cases and 24,272 controls from the international PRACTICAL Consortium. Twenty-three new prostate cancer susceptibility loci were identified at genome-wide significance (P < 5 × 10−8). More than 70 prostate cancer susceptibility loci, explaining ~30% of the familial risk for this disease, have now been identified. On the basis of combined risks conferred by the new and previously known risk loci, the top 1% of the risk distribution has a 4.7-fold higher risk than the average of the population being profiled. These results will facilitate population risk stratification for clinical studies.

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ID Code: 57027
Item Type: Journal Article
Refereed: Yes
DOI: 10.1038/ng.2560
ISSN: 1061-4036
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 11 Feb 2013 01:27
Last Modified: 28 Nov 2013 02:56

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