Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland

Lambert, Stephen, Faux, Cassandra, Hall, Lisa, Birrell, Frances, Peterson , Karen, Selvey , Christine, Sloots , Theo, Nissen , Michael, & Grimwood , Keith (2009) Early evidence for direct and indirect effects of the infant rotavirus vaccine program in Queensland. Medical Journal of Australia, 191(3), pp. 157-160.

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Abstract

Objective:
To assess the impact of introducing a publicly funded infant rotavirus vaccination program on disease notifications and on laboratory testing and results.

Design and setting:
Retrospective analysis of routinely collected data (rotavirus notifications [2006–2008] and laboratory rotavirus testing data from Queensland Health laboratories [2000–2008]) to monitor rotavirus trends before and after the introduction of a publicly funded infant rotavirus vaccination program in Queensland in July 2007.

Main outcome measures:
Age group-specific rotavirus notification trends; number of rotavirus tests performed and the proportion positive.

Results:
In the less than 2 years age group, rotavirus notifications declined by 53% (2007) and 65% (2008); the number of laboratory tests performed declined by 3% (2007) and 15% (2008); and the proportion of tests positive declined by 45% (2007) and 43% (2008) compared with data collected before introduction of the vaccination program. An indirect effect of infant vaccination was seen: notifications and the proportion of tests positive for rotavirus declined in older age groups as well.

Conclusions:
The publicly funded rotavirus vaccination program in Queensland is having an early impact, direct and indirect, on rotavirus disease as assessed using routinely collected data. Further observational studies are required to assess vaccine effectiveness. Parents and immunisation providers should ensure that all Australian children receive the recommended rotavirus vaccine doses in the required timeframe.

Impact and interest:

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ID Code: 57083
Item Type: Journal Article
Refereed: Yes
Keywords: rotavirus, immunisation, vaccine efficacy
ISSN: 0025-729X
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Epidemiology (111706)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700) > Preventive Medicine (111716)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 11 Feb 2013 03:08
Last Modified: 11 Jun 2013 05:11

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