Recruitment and results of a pilot trial of vitamin D supplementation in the general population of Australia

Tran, Bich, Armstrong, Bruce K., Carlin, John B, Ebeling, Peter R, English, Dallas R., Kimlin, Michael G., Rahman, Bayzidur, van der Pols, Jolieke C., Venn, Alison, Gebski, Val, Whiteman, David C., & Webb, Penelope (2012) Recruitment and results of a pilot trial of vitamin D supplementation in the general population of Australia. Journal of Clinical Endocrinology and Metabolism, 97(12), pp. 4473-4480.

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Context: The benefits of high serum levels of 25-hydroxyvitamin D [25(OH)D] are unclear. Trials are needed to establish an appropriate evidence base.

Objective: We plan to conduct a large-scale trial of vitamin D supplementation for the reduction of cancer incidence and overall mortality and report here the methods and results of a pilot trial established to inform its design. Design: Pilot D-Health was a randomized trial carried out in a general community setting with 12 months intervention and follow-up. Participants: Participants were 60- to 84-yr-old residents of one of the four eastern Australian states who did not have any vitamin D-related disorders and who were not taking more than 400 IU supplementary vitamin D per day. A total of 644 participants were randomized, and 615 completed the study (two persons withdrew because of nonserious adverse events). Interventions: The interventions were monthly doses of placebo or 30,000 or 60,000 IU vitamin D3.

Main Outcomes: The main outcomes were the recruitment rate and changes in serum 25(OH)D. Results: Ten percent of those approached were recruited. At baseline, the mean 25(OH)D was 42 nmol/liter in all three study arms. The mean change in 25(OH)D in the placebo group was 0.12 nmol/liter, compared with changes of 22 and 36 nmol/liter in the 30,000- and 60,000-IU groups, respectively.

Conclusions: The D-Health pilot has shown that a large trial is feasible in Australia and that a dose of 2000 IU/d will be needed to ensure that a large proportion of the population reaches the target serum 25(OH)D level.

Copyright © 2012 by The Endocrine Society.

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ID Code: 57392
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1210/jc.2012-2682
ISSN: 1945-7197 (online) 0021-972X (print)
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > PUBLIC HEALTH AND HEALTH SERVICES (111700)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2012 by The Endocrine Society
Deposited On: 04 Mar 2013 22:04
Last Modified: 12 Jun 2013 15:32

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