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Cone-mediated multifocal electroretinogram (mfERG) in early age-related maculopathy (early ARM) and its relationship with subjective macular function tests

Feigl, Beatrix, Brown, Brian, Lovie-Kitchin, Jan E., & Swann, Peter G. (2004) Cone-mediated multifocal electroretinogram (mfERG) in early age-related maculopathy (early ARM) and its relationship with subjective macular function tests. Current Eye Research, 29(4-5), pp. 327-336.

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Abstract

Purpose. To investigate the multifocal electroretinogram (mfERG) and subjective function in early age-related maculopathy (ARM).

Methods. Seventeen subjects with early ARM with visual acuity (VA) of 6/12 or better and 20 age-matched control subjects were examined. We assessed mfERGs, high and low contrast distance VA, near VA, low luminance VA, contrast sensitivity, saturated and desaturated Panel D-15 and visual fields (mean sensitivity). The mfERG responses were analysed by comparing central-overall (method 1) and superior-inferior (method 2) ratios.

Results. The mfERG did not discriminate between the groups whereas colour vision (tritan deficiency), contrast sensitivity, and high contrast and low contrast VA showed significantly reduced responses for the early ARM group compared with the control group (p ≤ 0.01). The mfERG first-order kernel responses correlated significantly with the desaturated D-15 in both methods (r = −0.5, p ≤ 0.05). Fundus grading was not correlated with the mfERG measures.

Conclusions. Although the mfERG correlated significantly with the desaturated D-15 in early ARM, suggesting it operates at a sensitive level, it failed to discriminate between the control and ARM groups. In our sample, the subjective function measures were more sensitive than the mfERG measures.

Impact and interest:

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17 citations in Web of Science®

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ID Code: 5767
Item Type: Journal Article
Additional Information: For more information, please refer to the journal’s website (see link) or contact the author. Author contact details: b.feigl@qut.edu.au
Keywords: age, related maculopathy, early ARM, mfERG, multifocal electroretinogram
DOI: 10.1080/02713680490516198
ISSN: 1460-2202
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2004 Taylor & Francis
Copyright Statement: First published in Current Eye Research 29(4-5):pp. 327-336.
Deposited On: 25 Jul 2007
Last Modified: 29 Feb 2012 23:09

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