The human tissue kallikrein and kallikrein-related peptidase family

Clements, Judith, Hooper, John, & Dong, Ying (2013) The human tissue kallikrein and kallikrein-related peptidase family. In Rawlings, Neil & Salvesen, Guy (Eds.) Handbook of Proteolytic Enzymes [3rd ed.]. Academic Press (Elsevier), New York & London, pp. 2747-2756.

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Abstract

The human kallikrein-related peptidases are a subgroup of trypsin and chymotrypsin-like serine peptidases that are characterized by their homology to tissue kallikrein or kallikrein 1 (KLK1) encoded by the KLK1 gene (reviewed in[1-4]). The human KLK locus spans an approximately 320 kb region on chromosome 19q13.3-13.4 and contains fifteen genes encoding KLK1 and fourteen other kallikrein-related peptidases, KLK2-KLK15, which have been named contiguously in the locus in the order of their discovery [5-8] (Figure 606.1). It is the largest contiguous cluster of serine protease encoding genes in the human genome which has evolved from gene duplication of KLK1 and then subsequent reduplication of the newly evolved KLK genes [2]. The high conservation noted for KLK1-KLK3 (62-77%) reflects the proposed duplication of the KLK1 gene that produced the KLK2 gene which further generated the KLK3 gene. In contrast, the newer KLK4-KLK15 proteases share much less similarity, from 24-66%, although strong homology between KLK4 and KLK5, KLK9 and KLK11, and KLK10 and KLK12 suggests these genes are duplications of each other [2]...

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ID Code: 57713
Item Type: Book Chapter
Keywords: Kallikrein-relatedpeptidase, Gene, Proteolytic activity
ISBN: 9780123822192
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000)
Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Elsevier
Deposited On: 04 Mar 2013 01:16
Last Modified: 21 Oct 2015 16:23

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