Role of resting metabolic rate and energy expenditure in hunger and appetite control : a new formulation

Blundell, John E., Caudwell, Phillipa, Gibbons, Catherine, Hopkins, Mark, Naslund, Erik, King, Neil A., & Finlayson, Graham (2012) Role of resting metabolic rate and energy expenditure in hunger and appetite control : a new formulation. Disease Models & Mechanisms, 5(5), pp. 608-613.

View at publisher


A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that "the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy". However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity.

Impact and interest:

54 citations in Scopus
45 citations in Web of Science®
Search Google Scholar™

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

Full-text downloads:

252 since deposited on 07 Mar 2013
14 in the past twelve months

Full-text downloads displays the total number of times this work’s files (e.g., a PDF) have been downloaded from QUT ePrints as well as the number of downloads in the previous 365 days. The count includes downloads for all files if a work has more than one.

ID Code: 57921
Item Type: Journal Article
Refereed: Yes
DOI: 10.1242/dmm.009837
ISSN: 1754-8411
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2012 The Company of Biologists Ltd
Deposited On: 07 Mar 2013 04:28
Last Modified: 17 Jul 2017 23:01

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page