Role of resting metabolic rate and energy expenditure in hunger and appetite control : a new formulation

Blundell, John E., Caudwell, Phillipa, Gibbons, Catherine, Hopkins, Mark, Naslund, Erik, King, Neil A., & Finlayson, Graham (2012) Role of resting metabolic rate and energy expenditure in hunger and appetite control : a new formulation. Disease Models & Mechanisms, 5(5), pp. 608-613.

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Abstract

A long-running issue in appetite research concerns the influence of energy expenditure on energy intake. More than 50 years ago, Otto G. Edholm proposed that "the differences between the intakes of food [of individuals] must originate in differences in the expenditure of energy". However, a relationship between energy expenditure and energy intake within any one day could not be found, although there was a correlation over 2 weeks. This issue was never resolved before interest in integrative biology was replaced by molecular biochemistry. Using a psychobiological approach, we have studied appetite control in an energy balance framework using a multi-level experimental system on a single cohort of overweight and obese human subjects. This has disclosed relationships between variables in the domains of body composition [fat-free mass (FFM), fat mass (FM)], metabolism, gastrointestinal hormones, hunger and energy intake. In this Commentary, we review our own and other data, and discuss a new formulation whereby appetite control and energy intake are regulated by energy expenditure. Specifically, we propose that FFM (the largest contributor to resting metabolic rate), but not body mass index or FM, is closely associated with self-determined meal size and daily energy intake. This formulation has implications for understanding weight regulation and the management of obesity.

Impact and interest:

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ID Code: 57921
Item Type: Journal Article
Refereed: Yes
DOI: 10.1242/dmm.009837
ISSN: 1754-8411
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2012 The Company of Biologists Ltd
Deposited On: 07 Mar 2013 04:28
Last Modified: 10 Mar 2013 04:20

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