Effect of chronic exercise on appetite control in overweight and obese individuals

Martins, Catia, Kulseng, Bard, Rehfeld, Jens F., King, Neil A., & Blundell, John E. (2013) Effect of chronic exercise on appetite control in overweight and obese individuals. Medicine and Science in Sports and Exercise, 45(5), pp. 805-812.

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Abstract

Purpose: The effect of exercise on body mass is likely to be partially mediated through changes in appetite control. However, no studies have examined the effect of chronic exercise on obestatin and cholecystokinin (CCK) plasma concentrations or the sensitivity to detect differences in preload energy in obese individuals. The objective of this study was to investigate the effects of chronic exercise on 1) fasting and postprandial plasma concentrations of obestatin, CCK, leptin, and glucose insulinotropic peptide (GIP) and 2) the accuracy of energy compensation in response to covert preload manipulation.

Methods: This study used a 12-wk supervised exercise program in 22 sedentary overweight/obese individuals. Fasting/postprandial plasma concentrations of obestatin, CCK, leptin, and GIP were assessed before and after the intervention. Energy compensation at a 30-min test meal after a high-energy (607 kcal) or a low-energy (246 kcal) preload and for the rest of the day (cumulative energy intake [EI]) was also measured.

Results: There was a significant reduction in the plasma concentration of fasting plasma GIP and both fasting and postprandial leptin concentrations after the exercise intervention (P < 0.05 for all). No significant changes were observed for CCK or obestatin. A significant preload–exercise interaction (P = 0.011) was observed on cumulative EI and energy compensation for the same period (−87% ± 196% vs 68% ± 165%, P = 0.011). Weight loss (3.5 ± 1.4 kg, P < 0.0001) was not correlated with changes in energy compensation.

Conclusions: This study suggests that exercise improves the accuracy of compensation for previous EI, independent of weight loss. Unexpectedly, and in contrast to GIP and leptin, exercise-induced weight loss had no effect on obestatin or CCK concentrations.

Impact and interest:

15 citations in Scopus
11 citations in Web of Science®
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ID Code: 57926
Item Type: Journal Article
Refereed: Yes
DOI: 10.1249/MSS.0b013e31827d1618
ISSN: 0195-9131
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 American College of Sports Medicine
Copyright Statement: This is a non-final version of an article published in final form in Medicine & Science in Sports & Exercise:
May 2013 - Volume 45 - Issue 5 - p 805–812
Deposited On: 07 Mar 2013 05:24
Last Modified: 23 Jun 2017 22:29

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