Morphology-based model for predicting osteocyte-like cell line (MLO-Y4) growth process

Yuan, Huan, Steinberg, Theodore, Gu, YuanTong, & Xiao, Yin (2012) Morphology-based model for predicting osteocyte-like cell line (MLO-Y4) growth process. In Gu, YuanTong & Saha, Suvash C. (Eds.) 4th International Conference on Computational Methods (ICCM 2012), 25-28 November 2012, Crowne Plaza, Gold Coast, QLD.

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Abstract

This work has led to the development of empirical mathematical models to quantitatively predicate the changes of morphology in osteocyte-like cell lines (MLO-Y4) in culture. MLO-Y4 cells were cultured at low density and the changes in morphology recorded over 11 hours. Cell area and three dimensional shape features including aspect ratio, circularity and solidity were then determined using widely accepted image analysis software (ImageJTM). Based on the data obtained from the imaging analysis, mathematical models were developed using the non-linear regression method. The developed mathematical models accurately predict the morphology of MLO-Y4 cells for different culture times and can, therefore, be used as a reference model for analyzing MLO-Y4 cell morphology changes within various biological/mechanical studies, as necessary.

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ID Code: 58128
Item Type: Conference Paper
Refereed: Yes
Keywords: Cell Morphology Analysis, Osteocyte-like cell line (MLO-Y4), Curve Fitting
ISBN: 9781921897542
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomechanical Engineering (090302)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 [please consult the author]
Deposited On: 13 Mar 2013 03:47
Last Modified: 27 Jan 2015 17:25

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