Continuum mechanics modelling of microfilament networks with different architectures based on molecular investigation of single F-actin

Li, Tong, Gu, YuanTong, Yarlagadda, Prasad K., & Oloyede, Adekunle (2012) Continuum mechanics modelling of microfilament networks with different architectures based on molecular investigation of single F-actin. In Gu, YuanTong & Saha, Suvash C. (Eds.) Proceedings of the 4th International Conference on Computational Methods, Crowne Plaza, Gold Coast, QLD.

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Abstract

The actin microfilament plays a critical role in many cellular processes including embryonic development, wound healing, immune response, and tissue development. It is commonly organized in the form of networks whose mechanical properties change with changes in their architecture due to cell evolution processes. This paper presents a new nonlinear continuum mechanics model of single filamentous actin (F-actin) that is based on nanoscale molecular simulations. Following this continuum model of the single F-actin, mechanical properties of differently architected lamellipodia are studied. The results provide insight that can contribute to the understanding of the cell edge motions of living cells.

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ID Code: 58149
Item Type: Conference Paper
Refereed: Yes
ISBN: 9781921897542
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Structural Biology (incl. Macromolecular Modelling) (060112)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 [please consult the author]
Deposited On: 13 Mar 2013 22:38
Last Modified: 18 Mar 2013 04:43

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