Proteomic and bioinformatics tools to understand virulence mechanisms in Staphylococcus aureus

Hussain, Malik Asif & Huygens, Flavia (2012) Proteomic and bioinformatics tools to understand virulence mechanisms in Staphylococcus aureus. Current Proteomics, 9(1), pp. 2-8.

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Abstract

Staphylococcus aureus, one of the major pathogenic bacteria, is associated with substantial morbidity and mortality. The disease burden of staphylococcal infections is significant, which is primarily attributed to its adaptability and resistance to environmental stresses. S. aureus has the ability to develop multiple resistances to antimicrobial agents. These high resistances make pathogenicity of S. aureus one of the most complex mechanisms to understand and manage. Proteomic and bioinformatics approaches show great potential in exploring microbial adaptation strategies, ability to cause disease by pathogenic bacteria and the development of diagnostic tools. A summary of the latest developments in the application of ‘omics’ technologies to understand resistance mechanisms in S. aureus and their future role in antistaphylococcal vaccine and/or drug discovery is given here.

Impact and interest:

3 citations in Scopus
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3 citations in Web of Science®

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ID Code: 58200
Item Type: Journal Article
Refereed: Yes
Keywords: bioinformatics, methicillin-resistant, pathogenicity, proteomics, Staphylococcus aureus, virulence
DOI: 10.2174/157016412799746245
ISSN: 1570-1646
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > MICROBIOLOGY (060500) > Infectious Agents (060502)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2012 Bentham Science Publishers
Deposited On: 14 Mar 2013 03:47
Last Modified: 20 Mar 2013 00:45

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