Ventilation distribution in rats : Part I - The effect of gas composition as measured with electrical impedance tomography
Dunster, Kimble R., Friese, Marlies, Fraser, John F., Cowin, Gary J., & Schibler, Andreas (2012) Ventilation distribution in rats : Part I - The effect of gas composition as measured with electrical impedance tomography. BioMedical Engineering OnLine, 11(1), p. 64.
The measurement of ventilation distribution is currently performed using inhaled tracer gases for multiple breath inhalation studies or imaging techniques to quantify spatial gas distribution. Most tracer gases used for these studies have properties different from that of air. The effect of gas density on regional ventilation distribution has not been studied. This study aimed to measure the effect of gas density on regional ventilation distribution.
Methods Ventilation distribution was measured in seven rats using electrical impedance tomography (EIT) in supine, prone, left and right lateral positions while being mechanically ventilated with either air, heliox (30% oxygen, 70% helium) or sulfur hexafluoride (20% SF6, 20% oxygen, 60% air). The effect of gas density on regional ventilation distribution was assessed.
Results Gas density did not impact on regional ventilation distribution. The non-dependent lung was better ventilated in all four body positions. Gas density had no further impact on regional filling characteristics. The filling characteristics followed an anatomical pattern with the anterior and left lung showing a greater impedance change during the initial phase of the inspiration.
Conclusion It was shown that gas density did not impact on convection dependent ventilation distribution in rats measured with EIT.
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|Item Type:||Journal Article|
|Keywords:||Electrical impedance tomography, Ventilation distribution|
|Subjects:||Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > CLINICAL SCIENCES (110300) > Intensive Care (110310)|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > QUT Faculties and Divisions > Faculty of Health
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012 Dunster et al.; licensee BioMed Central Ltd|
|Copyright Statement:||This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.|
|Deposited On:||18 Mar 2013 03:33|
|Last Modified:||18 Sep 2013 03:35|
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