Eyes on 3D-Current 3D biomimetic disease concept models and potential applications in age-related macular degeneration

Feigl, Beatrix & Hutmacher, Dietmar (2013) Eyes on 3D-Current 3D biomimetic disease concept models and potential applications in age-related macular degeneration. Advanced Healthcare Materials.

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Abstract

Three dimensional cellular models that mimic disease are being increasingly investigated and have opened an exciting new research area into understanding pathomechanisms. The advantage of 3D in vitro disease models is that they allow systematic and in-depth studies of physiological and pathophysiological processes with less costs and ethical concerns that have arisen with animal models. The purpose of the 3D approach is to allow crosstalk between cells and microenvironment, and with cues from the microenvironment, cells can assemble their niche similar to in vivo conditions. The use of 3D models for mimicking disease processes such as cancer, osteoarthritis etc., is only emerging and allows multidisciplinary teams consisting of tissue engineers, biologist biomaterial scientists and clinicians to work closely together. While in vitro systems require rigorous testing before they can be considered as replicates of the in vivo model, major steps have been made, suggesting that they will become powerful tools for studying physiological and pathophysiological processes. This paper aims to summarize some of the existing 3D models and proposes a novel 3D model of the eye structures that are involved in the most common cause of blindness in the Western World, namely age-related macular degeneration (AMD).

Impact and interest:

4 citations in Scopus
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4 citations in Web of Science®

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ID Code: 58324
Item Type: Journal Article
Refereed: Yes
Additional Information: Early View (Online Version of Record published before inclusion in an issue)
Keywords: Three-dimensional cell culture models;3D disease concepts;age-related macular degeneration
DOI: 10.1002/adhm.201200445
ISSN: 2192-2659
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > BIOCHEMISTRY AND CELL BIOLOGY (060100) > Cellular Interactions (incl. Adhesion Matrix Cell Wall) (060106)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300) > Ophthalmology (111301)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Copyright Statement: The definitive version is available at www3.interscience.wiley.com
Deposited On: 17 Mar 2013 22:34
Last Modified: 29 Oct 2016 03:00

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