Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses

Hernandez Sanchez, J., Chatzpili, A., Beraldi, D., Gratten , J., Pilkington, J. G., & Pemberton, J. M. (2010) Mapping quantitative trait loci in a wild population using linkage and linkage disequilibrium analyses. Genetics Research, 92(4), pp. 273-281.

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Historical information can be used, in addition to pedigree, traits and genotypes, to map quantitative trait locus (QTL) in general populations via maximum likelihood estimation of variance components. This analysis is known as linkage disequilibrium (LD) and linkage mapping, because it exploits both linkage in families and LD at the population level. The search for QTL in the wild population of Soay sheep on St. Kilda is a proof of principle. We analysed the data from a previous study and confirmed some of the QTLs reported. The most striking result was the confirmation of a QTL affecting birth weight that had been reported using association tests but not when using linkage-based analyses. Copyright © Cambridge University Press 2010.

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ID Code: 58633
Item Type: Journal Article
Refereed: Yes
Keywords: article; birth weight; body weight; gene linkage disequilibrium; gene mapping; genetic association; nonhuman; quantitative trait locus; sheep, Alleles; Animals; Chromosome Mapping; Genetic Markers; Linkage Disequilibrium; Microsatellite Repeats; Models, Statistical; Phenotype; Quantitative Trait Loci; Sheep, Ovis aries
DOI: 10.1017/S0016672310000340
ISSN: 0016-6723
Subjects: Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000) > ANIMAL PRODUCTION (070200) > Animal Breeding (070201)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2010 Cambridge University Press
Deposited On: 26 Mar 2013 00:23
Last Modified: 06 May 2013 03:40

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