Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy

Zhang, Chi, de Koning, Dirk-Jan , Hernandez Sanchez, Julio, Haley, Chris S., Williams, John L., & Wiener, Pamela (2004) Mapping of multiple quantitative trait loci affecting bovine spongiform encephalopathy. Genetics, 167(4), pp. 1863-1872.

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A whole-genome scan was conducted to map quantitative trait loci (QTL) for BSE resistance or susceptibility. Cows from four half-sib families were included and 173 microsatellite markers were used to construct a 2835-cM (Kosambi) linkage map covering 29 autosomes and the pseudoautosomal region of the sex chromosome. Interval mapping by linear regression was applied and extended to a multiple-QTL analysis approach that used identified QTL on other chromosomes as cofactors to increase mapping power. In the multiple-QTL analysis, two genome-wide significant QTL (BTA17 and X/Y ps) and four genome-wide suggestive QTL (BTA1, 6, 13, and 19) were revealed. The QTL identified here using linkage analysis do not overlap with regions previously identified using TDT analysis. One factor that may explain the disparity between the results is that a more extensive data set was used in the present study. Furthermore, methodological differences between TDT and linkage analyses may affect the power of these approaches.

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ID Code: 58642
Item Type: Journal Article
Refereed: Yes
Additional Information: Articles free to read on journal website after 12 months
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Keywords: animal experiment; article; autosome; bovine spongiform encephalopathy; controlled study; cow; disease predisposition; disease resistance; family; gene mapping; genetic linkage; genome; genome analysis; methodology; microsatellite marker; nonhuman; priori, Animals; Cattle; Chromosome Mapping; Confidence Intervals; Encephalopathy, Bovine Spongiform; Genetic Markers; Genome; Genotype; Models, Genetic; Quantitative Trait Loci, Animalia; Bovinae
DOI: 10.1534/genetics.104.026401
ISSN: 0016-6731
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Quantitative Genetics (incl. Disease and Trait Mapping Genetics (060412)
Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000) > ANIMAL PRODUCTION (070200) > Animal Breeding (070201)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 25 Mar 2013 02:56
Last Modified: 29 Jan 2015 04:42

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