Power of QTL detection using association tests with family controls

Hernandez Sanchez, Julio, Haley, Chris S., & Visscher, Peter (2003) Power of QTL detection using association tests with family controls. European Journal of Human Genetics, 11(11), pp. 819-827.

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The power of testing for a population-wide association between a biallelic quantitative trait locus and a linked biallelic marker locus is predicted both empirically and deterministically for several tests. The tests were based on the analysis of variance (ANOVA) and on a number of transmission disequilibrium tests (TDT). Deterministic power predictions made use of family information, and were functions of population parameters including linkage disequilibrium, allele frequencies, and recombination rate. Deterministic power predictions were very close to the empirical power from simulations in all scenarios considered in this study. The different TDTs had very similar power, intermediate between one-way and nested ANOVAs. One-way ANOVA was the only test that was not robust against spurious disequilibrium. Our general framework for predicting power deterministically can be used to predict power in other association tests. Deterministic power calculations are a powerful tool for researchers to plan and evaluate experiments and obviate the need for elaborate simulation studies.

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ID Code: 58644
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: allele; analysis of variance; article; controlled study; family; gene control; gene frequency; gene function; gene linkage disequilibrium; gene mapping; genetic analysis; genetic marker; genetic parameters; genetic recombination; genetic screening; genoty, Analysis of Variance; Gene Frequency; Genetic Markers; Genetics, Population; Humans; Linkage Disequilibrium; Probability; Quantitative Trait Loci
DOI: 10.1038/sj.ejhg.5201042
ISSN: 1476-5438
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Quantitative Genetics (incl. Disease and Trait Mapping Genetics (060412)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 26 Mar 2013 03:23
Last Modified: 26 Mar 2013 03:23

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