Genome-wide search for markers associated with bovine spongiform encephalopathy

Hernandez Sanchez, Jules, Waddington, Dave, Wiener, Pamela, Haley, Chris S., & Williams, John L. (2002) Genome-wide search for markers associated with bovine spongiform encephalopathy. Mammalian Genome, 13(3), pp. 164-168.

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A genome-wide search for markers associated with BSE incidence was performed by using Transmission-Disequilibrium Tests (TDTs). Significant segregation distortion, i.e., unequal transmission probabilities of alleles within a locus, was found for three marker loci on Chromosomes (Chrs) 5, 10, and 20. Although TDTs are robust to false associations owing to hidden population substructures, it cannot distinguish segregation distortion caused by a true association between a marker and bovine spongiform encephalopathy (BSE) from a population-wide distortion.

An interaction test and a segregation distortion analysis in half-sib controls were used to disentangle these two alternative hypotheses. None of the markers showed any significant interaction between allele transmission rates and disease status, and only the marker on Chr 10 showed a significant segregation distortion in control individuals. Nevertheless, the control group may have been a mixture of resistant and susceptible but unchallenged individuals. When new genotypes were generated in the vicinity of these three markers, evidence for an association with BSE was confirmed for the locus on Chr 5.

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ID Code: 58648
Item Type: Journal Article
Refereed: Yes
Keywords: animal tissue; article; bovine spongiform encephalopathy; chromosome 10; chromosome 20; chromosome 5; gene linkage disequilibrium; gene locus; genotype; nonhuman, Animals; Cattle; Chromosome Mapping; Encephalopathy, Bovine Spongiform; Female; Genetic Markers; Genetic Predisposition to Disease; Genome; Great Britain; Immunity, Natural; Linkage Disequilibrium; Male, Animalia; Bovinae
DOI: 10.1007/BF02684022
ISSN: 1432-1777
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000) > GENETICS (060400) > Quantitative Genetics (incl. Disease and Trait Mapping Genetics (060412)
Australian and New Zealand Standard Research Classification > AGRICULTURAL AND VETERINARY SCIENCES (070000) > ANIMAL PRODUCTION (070200) > Animal Breeding (070201)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 26 Mar 2013 23:29
Last Modified: 27 Mar 2013 01:33

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