Preparing nanocomposite fibrous scaffolds of P3HB/nHA for bone tissue engineering

Heidarkhan Tehrani, Ashkan & Saeed, Karbasi (2010) Preparing nanocomposite fibrous scaffolds of P3HB/nHA for bone tissue engineering. In Proceedings of the 17th Iranian Conference of Biomedical Engineering, IEEE, Isfahan University of Medical Isfahan, Iran, pp. 403-406.

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Abstract

Nanocomposites are recently known to be among the most successful materials in biomedical applications. In this work we sought to fabricate fibrous scaffolds which can mimic the extra cellular matrix of cartilaginous connective tissue not only to a structural extent but with a mechanical and biological analogy. Poly(3-hydroxybutyrate) (P3HB) matrices were reinforced with 5, 10 and 15 %wt hydroxyapatite (HA) nanoparticles and electrospun into nanocomposite fibrous scaffolds. Mechanical properties of each case were compared with that of a P3HB scaffold produced in the same processing condition. Spectroscopic and morphological observations were used for detecting the interaction quality between the constituents. Nanoparticles rested deep within the fibers of 1 μm in diameter. Chemical interactions of hydrogen bonds linked the constituents through the interface. Maximum elastic modulus and mechanical strength was obtained with the presence of 5%wt hydroxyapatite nanoparticles. Above 10%wt, nanoparticles tended to agglomerate and caused the entity to lose its mechanical performance; however, viscoelasticity interfered at this concentration and lead to a delayed failure. In other words, higher elongation at break and a massive work of rupture was observed at 10%wt.

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ID Code: 58967
Item Type: Conference Paper
Refereed: No
Additional URLs:
Keywords: Nanocomposite, Fibrous scaffolds, Bone Tissue engineering, Poly(3-hydroxybutyrate), Hydroxyapatite
DOI: 10.1109/ICBME.2010.5705012
ISBN: 9781424474844
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Composite and Hybrid Materials (091202)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Polymers and Plastics (091209)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Solid Mechanics (091308)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 09 Apr 2013 23:39
Last Modified: 25 Jul 2013 00:02

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