Scaffold percolative efficiency : in vitro evaluation of the structural criterion for electrospun mats

Heidarkhan Tehrani, A., Zadhoush, A., Karbasi, S., & Sadeghi-Aliabadi, H. (2010) Scaffold percolative efficiency : in vitro evaluation of the structural criterion for electrospun mats. Journal of Materials Science : Materials in Medicine, 21(11), pp. 2989-2998.

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Abstract

Fibrous scaffolds of engineered structures can be chosen as promising porous environments when an approved criterion validates their applicability for a specific medical purpose. For such biomaterials, this paper sought to investigate various structural characteristics in order to determine whether they are appropriate descriptors. A number of poly(3-hydroxybutyrate) scaffolds were electrospun; each of which possessed a distinguished architecture when their material and processing conditions were altered. Subsequent culture of mouse fibroblast cells (L929) was carried out to evaluate the cells viability on each scaffold after their attachment for 24 h and proliferation for 48 and 72 h. The scaffolds’ porosity, pores number, pores size and distribution were quantified and none could establish a relationship with the viability results. Virtual reconstruction of the mats introduced an authentic criterion, “Scaffold Percolative Efficiency” (SPE), with which the above descriptors were addressed collectively. It was hypothesized to be able to quantify the efficacy of fibrous scaffolds by considering the integration of porosity and interconnectivity of the pores. There was a correlation of 80% as a good agreement between the SPE values and the spectrophotometer absorbance of viable cells; a viability of more than 350% in comparison to that of the controls.

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6 citations in Web of Science®

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ID Code: 59006
Item Type: Journal Article
Refereed: Yes
Additional URLs:
DOI: 10.1007/s10856-010-4149-7
ISSN: 1573-4838
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > CHEMICAL ENGINEERING (090400)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > CHEMICAL ENGINEERING (090400) > Rheology (090408)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MATERIALS ENGINEERING (091200) > Polymers and Plastics (091209)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Copyright Owner: Copyright 2010 Springer New York LLC
Deposited On: 08 Apr 2013 22:28
Last Modified: 20 Jan 2014 01:45

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