Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting : a systematic literature review

Marx, Wolfgang M, Teleni, Laisa, McCarthy, Alexandra L., Vitetta, Luis, McKavanagh, Dan, Thomson, Damien, & Isenring, Elisabeth (2013) Ginger (Zingiber officinale) and chemotherapy-induced nausea and vomiting : a systematic literature review. Nutrition Reviews, 71(4), pp. 245-254.

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Chemotherapy-induced nausea and vomiting (CINV) is a common side-effect of cytotoxic treatment. It continues to affect a significant proportion of patients despite the widespread use of anti-emetic medication. In folk-medicine, ginger (Zingiber officinale) has been used to prevent and treat nausea in many cultures for thousands of years. However, its use has not been validated in the chemotherapy context. To determine the potential use of ginger as a prophylactic or treatment of CINV, a systematic literature review was conducted. Reviewed studies comprised randomised controlled trials or cross-over trials that investigated the anti-CINV effect of ginger as the sole intervention independent variable in chemotherapy patients. Seven studies met the inclusion criteria. All studies were assessed on methodological quality and their limitations were identified. Studies were mixed in their support of ginger as an anti-CINV treatment in patients receiving chemotherapy, with three demonstrating a positive effect, two in favour but with caveats and two showing no effect on measures of CINV. Future studies are required to address the limitations identified before clinical use can be recommended.

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ID Code: 59091
Item Type: Journal Article
Refereed: Yes
Keywords: chemotherapy, CINV, ginger, nausea
DOI: 10.1111/nure.12016
ISSN: 0029-6643
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Current > Schools > School of Nursing
Current > Schools > School of Public Health & Social Work
Copyright Owner: Copyright 2013 International Life Sciences Institute
Copyright Statement: The definitive version is available at
Deposited On: 16 Apr 2013 22:20
Last Modified: 06 Nov 2013 16:44

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