Rod and cone pathway signaling and interaction under mesopic illumination

Zele, Andrew J., Maynard, Michelle L., & Feigl, Beatrix (2013) Rod and cone pathway signaling and interaction under mesopic illumination. Journal of Vision, 13(1).

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This study investigates the time-course and post-receptoral pathway signaling of photoreceptor interactions when the rod (R) and three cone (L, M, S) photoreceptor classes contribute to mesopic vision. A four-primary photostimulator independently controls photoreceptor activity in human observers.

The first experiment defines the temporal adaptation response of receptoral (L-, S-cone, rod) and post-receptoral (LMS, LMSR,+L-M) signaling and interactions. Here we show that nonopponent cone-cone interactions (L-cone, LMS, LMSR) have monophasic temporal response patterns whereas opponent signals (+L-M, S-cone) show biphasic response patterns with slower recovery. By comparison, rod-cone interactions with nonopponent signals have faster adaptation responses and reduced sensitivity loss whereas opponent rod-cone interactions are small or absent. Additionally, the rod-rod interaction differs from these interaction types and acts to increase rod sensitivity due to temporal summation but with a slower time course.

The second experiment shows that the temporal profile of the rod signal alters the relative rod contributions to the three primary post-receptoral pathways. We demonstrate that rod signals generate luminance (þLþM) signals mediated via the MC pathway with all rod temporal profiles and chromatic signals (L/LþM, S/LþM) in both the PC and KC pathways with durations .75 ms. Thus, we propose that the change in relative weighting of rod signals within the post-receptoral pathways contributes to the sensitivity and temporal response of rod and cone pathway signaling and interactions.

Impact and interest:

8 citations in Scopus
4 citations in Web of Science®
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75 since deposited on 25 Apr 2013
20 in the past twelve months

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ID Code: 59267
Item Type: Journal Article
Refereed: Yes
Funders: ARC
Keywords: mesopic, temporal, adaptation, rod-cone interaction, post-receptoral
DOI: 10.1167/13.1.21
ISSN: 1534-7362
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > OPTOMETRY AND OPHTHALMOLOGY (111300)
Divisions: Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Copyright Owner: Copyright 2013 Association for Research in Vision and Ophthalmology
Deposited On: 25 Apr 2013 22:25
Last Modified: 26 Jun 2017 14:42

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