An influenza virus inspired polymer system for the timed release of siRNA

Truong, Nghia P, Gu, Wenyi, Prasadam, Indira, Jia, Zhongfan, Crawford, Ross, Xiao, Yin, & Monteiro, Michael J (2013) An influenza virus inspired polymer system for the timed release of siRNA. Nature Communications, 4, p. 1902.

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Small interfering RNA silences specific genes by interfering with mRNA translation, and acts to modulate or inhibit specific biological pathways; a therapy that holds great promise in the cure of many diseases. However, the naked small interfering RNA is susceptible to degradation by plasma and tissue nucleases and due to its negative charge unable to cross the cell membrane. Here we report a new polymer carrier designed to mimic the influenza virus escape mechanism from the endosome, followed by a timed release of the small interfering RNA in the cytosol through a self-catalyzed polymer degradation process. Our polymer changes to a negatively charged and non-toxic polymer after the release of small interfering RNA, presenting potential for multiple repeat doses and long-term treatment of diseases.

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49 citations in Scopus
45 citations in Web of Science®
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ID Code: 59413
Item Type: Journal Article
Refereed: Yes
Keywords: influenza virus, polymer, siRNA
DOI: 10.1038/ncomms2905
ISSN: 2041-1723
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 06 Nov 2013 03:53
Last Modified: 15 Apr 2014 23:50

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