The key regulatory roles of the PI3K/Akt signalling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration

Chen, Jiezhong, Crawford, Ross, Chen, Chen, & Xiao, Yin (2013) The key regulatory roles of the PI3K/Akt signalling pathway in the functionalities of mesenchymal stem cells and applications in tissue regeneration. Tissue Engineering Part B: Reviews, 19(6), pp. 516-528.

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Mesenchymal stem cells (MSCs) are multi-potent cells that can differentiate into various cell types and have been used widely in tissue engineering application. In tissue engineering, a scaffold, MSCs and growth factors are used as essential components and their interactions have been regarded to be important for regeneration of tissues. A critical problem for MSCs in tissue engineering is their low survival ability and functionality. Most MSCs are going to be apoptotic after transplantation. Therefore, increasing MSC survival ability and functionalities is the key for potential applications of MSCs. Several approaches have been studied to increase MSC tissue forming capacity including application of growth factors, overexpression of stem cell regulatory genes and improvement of biomaterials for scaffolds. The effects of these approaches on MSCs have been associated with the activation of the PI3K/Akt signaling pathway. The pathway plays central regulatory roles in MSC survival, proliferation, migration, angiogenesis, cytokine production and differentiation. In this review, we summarize and discuss the literatures related to the roles of the PI3K/Akt pathway in the functionalities of MSCs and the involvement of the pathway in biomaterials-increased MSC functinalities. Biomaterials have been modified in their properties, surface structure and loaded with growth factors to increase MSC functionalities. Several studies demonstrated that the biomaterials-increased MSC functionalities are mediated by the activation of the PI3K/Akt pathway.

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39 citations in Scopus
38 citations in Web of Science®
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ID Code: 59511
Item Type: Journal Article
Refereed: Yes
Keywords: Mesenchymal stem cells, PI3K/Akt pathway, Survival ability, Migration, Angiogenesis, Cytokine production, Biomaterials
DOI: 10.1089/ten.teb.2012.0672
ISSN: 1937-3376
Subjects: Australian and New Zealand Standard Research Classification > BIOLOGICAL SCIENCES (060000)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Mary Ann Liebert, Inc.
Copyright Statement: This is a copy of an article published in the Tissue Engineering Part B: Reviews © 2013 [copyright Mary Ann Liebert, Inc.]; Tissue Engineering Part B: Reviews is available online at:
Deposited On: 13 Nov 2013 22:48
Last Modified: 23 Jun 2017 14:44

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