Insulin and the insulin-like growth factor system : a novel theory for hyperinsulinemic laminitis pathogenesis

de Laat, Melody A., Kyaw-Tanner, Myat, Patterson-Kane, Janet, Sillence, Martin, McGowan, Catherine, & Pollitt, Christopher (2011) Insulin and the insulin-like growth factor system : a novel theory for hyperinsulinemic laminitis pathogenesis. Journal of Equine Veterinary Science, 31(10), pp. 581-582.

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Abstract

Research into hyperinsulinemic laminitis has progressed significantly in recent years with the use of the prolonged-euglycemic, hyperinsulinemic clamp (p-EHC). Previous investigations of laminitis pathophysiology have focused on digital vascular dysfunction, inflammation, altered glucose metabolism within the lamellae, and lamellar basement membrane breakdown by metalloproteinases. The etiopathogenesis of laminitis occurring in association with hyperinsulinemia is yet to be fully characterized, but it may not involve these mechanisms.

Insulin stimulates cellular proliferation and can also affect other body systems, such as the insulin-like growth factor (IGF) system. Insulin-like growth factor-1 (IGF-1) is structurally homologous to insulin and, like insulin, binds with strong affinity to a specific tyrosine kinase receptor on the cell surface to produce its effects, which include promoting cell proliferation.

Receptors for IGF-1 (IGF-1R) are present in the lamellar epidermis. An alternative theory for the pathogenesis of hyperinsulinemic laminitis is that uncontrolled cell proliferation, mediated through both the insulin receptor (InsR) and IGF-1R, leads to lengthening, weakening, and failure of the lamellae. An analysis of the proliferative activity of lamellar epidermal cells during the developmental and acute phases of hyperinsulinemic laminitis, and lamellar gene expression of the InsR and IGF-1R was undertaken.

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ID Code: 59589
Item Type: Journal Article
Refereed: Yes
Keywords: Hyperinsulinemic Laminitis, Unique Pathogenesis, Insulin Receptor, Insulin-like Growth Factor-1 Receptor, Structural Failure
DOI: 10.1016/j.jevs.2011.09.031
ISSN: 0737-0806
Divisions: Past > Schools > Brisbane Graduate School of Business
Current > Schools > School of Earth, Environmental & Biological Sciences
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Deposited On: 02 May 2013 22:36
Last Modified: 10 Jul 2013 05:28

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