Effects of scaffold architecture on cranial bone healing
Berner, A., Woodruff, M.A., Lam, C.X.F., Arafat, M.T., Saifzadeh, S., Steck, R., Ren, J., Nerlich, M., Ekaputra, A.K., Gibson, I., & Hutmacher, D.W. (2013) Effects of scaffold architecture on cranial bone healing. International Journal of Oral & Maxillofacial Surgery, 43(4), pp. 506-513.
Scaffolds for bone tissue engineering should be designed to optimize cell migration, enhance new bone formation and give mechanical support. In the present study, we used polycaprolactone-tricalciumphosphate (PCL/TCP) scaffolds with two different fibre lay down patterns which were coated with hydroxyapatite and gelatine as an approach for optimizing bone regeneration in a critical sized calvarial defect. After 12 weeks bone regeneration was quantified using microCT analysis, biomechanical testing and histological evaluation. Notably, the experimental groups containing coated scaffolds showed lower bone formation and lower biomechanical properties within the defect compared to the uncoated scaffolds. Surprisingly, the different lay down pattern of the fibres resulted in different bone formation and biomechanical properties; namely 0/60/120° scaffolds revealed lower bone formation and biomechanical properties compared to the 0/90° scaffolds in all the experimental groups. The different architecture of the scaffold fibres may have an effect on nutrition supply as well as the attachment of the newly formed matrix to the scaffold. Therefore, future bone regeneration strategies utilising scaffolds should consider scaffold architecture as an important factor during the scaffold optimisation stages in order to move closer to a clinical application.
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|Item Type:||Journal Article|
|Keywords:||bone tissue engineering, scaffolds, polycaprolactone, lay down pattern, rat skull defect|
|Subjects:||Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2013 International Association of Oral and Maxillofacial Surgeons|
|Deposited On:||07 May 2013 23:39|
|Last Modified:||05 Sep 2016 06:50|
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