Chromatin modifications involved in the DNA damage response to double strand breaks

Pagan, Julia K., Bolderson, Emma, Jones, Mathew J. K., & Khanna, Kum Kum (2009) Chromatin modifications involved in the DNA damage response to double strand breaks. In Khanna, Kum Kum & Shiloh, Yosef (Eds.) The DNA Damage Response: Implications on Cancer Formation and Treatment. Springer, pp. 109-131.

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In eukaryotes, genomic DNA is tightly compacted into a protein-DNA complex known as chromatin. This dense structure presents a barrier to DNA-dependent processes including transcription, replication and DNA repair. The repressive structure of chromatin is overcome by ATP-dependent chromatin remodelling complexes and chromatin-modifying enzymes. There is now ample evidence that DNA double-strand breaks (DSBs) elicit various histone modifications (such as acetylation, deacetylation, and phosphorylation) that function combinatorially to control the dynamic structure of the chromatin microenvironment. The role of these mechanisms during transcription and replication has been well studied, while the research into their impact on regulation of DNA damage response is rapidly gaining momentum. How chromatin structure is remodeled in response to DNA damage and how such alterations influence DSB repair are currently significant questions. This review will summarise the major chromatin modifications and chromatin remodelling complexes implicated in the DNA damage response to DSBs.

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ID Code: 60141
Item Type: Book Chapter
DOI: 10.1007/978-90-481-2561-6_6
ISBN: 9789048125609
Subjects: Australian and New Zealand Standard Research Classification > MEDICAL AND HEALTH SCIENCES (110000) > ONCOLOGY AND CARCINOGENESIS (111200) > Cancer Cell Biology (111201)
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 21 May 2013 02:51
Last Modified: 22 Oct 2015 16:19

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