Hierarchical multiscale model for biomechanics analysis of microfilament networks

Li, Tong, Gu, YuanTong, Feng, XiQiao, Yarlagadda, Prasad K., & Oloyede, Adekunle (2013) Hierarchical multiscale model for biomechanics analysis of microfilament networks. Journal of Applied Physics, 113(19), pp. 194701-194707.

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Abstract

The mechanisms of force generation and transference via microfilament networks are crucial to the understandings of mechanobiology of cellular processes in living cells. However, there exists an enormous challenge for all-atom physics simulation of real size microfilament networks due to scale limitation of molecular simulation techniques. Following biophysical investigations of constitutive relations between adjacent globular actin monomers on filamentous actin, a hierarchical multiscale model was developed to investigate the biomechanical properties of microfilament networks. This model was validated by previous experimental studies of axial tension and transverse vibration of single F-actin. The biomechanics of microfilament networks can be investigated at the scale of real eukaryotic cell size (10 μm). This multiscale approach provides a powerful modeling tool which can contribute to the understandings of actin-related cellular processes in living cells.

Impact and interest:

5 citations in Scopus
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1 citations in Web of Science®

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ID Code: 60168
Item Type: Journal Article
Refereed: Yes
Additional URLs:
Keywords: Multiscale, Biomechanics, Microfilament networks, Coarse-Grained
DOI: 10.1063/1.4805029
ISSN: 1089-7550 (online) 0021-8979 (print)
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > MECHANICAL ENGINEERING (091300) > Numerical Modelling and Mechanical Characterisation (091307)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Schools > School of Civil Engineering & Built Environment
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 AIP Publishing LLC
Copyright Statement: Author's Pre-print: author can archive pre-print (ie pre-refereeing)
Author's Post-print: author can archive post-print (ie final draft post-refereeing)
Publisher's Version/PDF: author can archive publisher's version/PDF
•Publishers version/PDF may be used on author's personal website or institutional website
•Authors own version of final article on e-print servers
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•NIH-funded articles are automatically deposited with PubMed Central with open access after 12 months
Deposited On: 22 May 2013 23:16
Last Modified: 05 Jun 2013 20:28

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