Quantitative and qualitative assessment of the regenerative potential of osteoblasts versus bone marrow derived mesenchymal stem cells in the reconstruction of critical sized segmental tibial bone defects in a large animal model
Berner, Arne (2013) Quantitative and qualitative assessment of the regenerative potential of osteoblasts versus bone marrow derived mesenchymal stem cells in the reconstruction of critical sized segmental tibial bone defects in a large animal model. PhD by Publication, Queensland University of Technology.
This thesis is about the use of different cells for bone tissue engineering. The cells were used in combination with a novel biomaterial in a large tibial bone defects in a sheep model. Furthermore this study developed a novel cell delivery procedure for bone tissue engineering. This novel procedure of cell delivery could overcome the current problems of cell-based tissue engineering and serve as a baseline for the translation of novel concepts into clinical application.
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|Item Type:||QUT Thesis (PhD by Publication)|
|Supervisor:||Hutmacher, Dietmar & Schuetz, Michael|
|Keywords:||tissue engineering, bone regeneration, segmental bone defect, mesenchymal progenitor cells, preclinical animal model|
|Divisions:||Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Institution:||Queensland University of Technology|
|Deposited On:||15 Jul 2013 02:32|
|Last Modified:||08 Sep 2015 02:55|
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