Computer modeling of diffusion in biological tissues

Powell, Sean K. & Momot, Konstantin I. (2013) Computer modeling of diffusion in biological tissues. In Keser, Hafize (Ed.) AWER Procedia Information Technology & Computer Science, Academic World Education & Research Center, University of Barcelona, Barcelona, pp. 1227-1233.

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Molecular-level computer simulations of restricted water diffusion can be used to develop models for relating diffusion tensor imaging measurements of anisotropic tissue to microstructural tissue characteristics. The diffusion tensors resulting from these simulations can then be analyzed in terms of their relationship to the structural anisotropy of the model used. As the translational motion of water molecules is essentially random, their dynamics can be effectively simulated using computers. In addition to modeling water dynamics and water-tissue interactions, the simulation software of the present study was developed to automatically generate collagen fiber networks from user-defined parameters. This flexibility provides the opportunity for further investigations of the relationship between the diffusion tensor of water and morphologically different models representing different anisotropic tissues.

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ID Code: 61500
Item Type: Conference Paper
Refereed: Yes
Keywords: Computer simulation, Langevin dynamics, anistropic tissue, articular cartilage, collagen networks
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)
Divisions: Current > Schools > School of Chemistry, Physics & Mechanical Engineering
Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Academic World Education & Research Center
Deposited On: 22 Jul 2013 22:38
Last Modified: 24 Jul 2013 02:26

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