A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging

Yusuf, Kenny, Momot, Konstantin I., Wellard, R. Mark, & Oloyede, Adekunle (2013) A study of the diffusion characteristics of normal, delipidized and relipidized articular cartilage using magnetic resonance imaging. Journal of Materials Science : Materials in Medicine, 24(4), pp. 1005-1013.

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Abstract

This paper assesses the capacity to provide semipermeability of the synthetic layer of surface-active phospholipids created to replace the depleted surface amorphous layer of articular cartilage. The surfaces of articular cartilage specimens in normal, delipidized, and relipidized conditions following incubation in dipalmitoyl-phosphatidylcholine and palmitoyl-oleoyl-phosphatidylcholine components of the joint lipid mixture were characterized nanoscopically with the atomic force microscope and also imaged as deuterium oxide (D2O) diffused transiently through these surfaces in a magnetic resonance imaging enclosure. The MR images were then used to determine the apparent diffusion coefficients in a purpose-built MATLAB®-based algorithm. Our results revealed that all surfaces were permeable to D2O, but that there was a significant difference in the semipermeability of the surfaces under the different conditions, relative to the apparent diffusion coefficients. Based on the results and observations, it can be concluded that the synthetic lipid that is deposited to replace the depleted SAL of articular cartilage is capable of inducing some level of semipermeability.

Impact and interest:

2 citations in Scopus
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1 citations in Web of Science®

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ID Code: 61527
Item Type: Journal Article
Refereed: Yes
Keywords: Articular cartilage surface, Semipermeability, Apparent diffusion coefficient, Surface amorphous layer, Surface-active phospholipids, Magnetic resonance imaging
DOI: 10.1007/s10856-013-4858-9
ISSN: 1573-4838
Subjects: Australian and New Zealand Standard Research Classification > PHYSICAL SCIENCES (020000) > OTHER PHYSICAL SCIENCES (029900) > Medical Physics (029903)
Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 Springer Science+Business Media
Copyright Statement: The final publication is available at link.springer.com
Deposited On: 24 Jul 2013 22:51
Last Modified: 08 May 2014 07:35

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