Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based
Dey Sarkar, Soumi, Farrugia, Brooke L., Dargaville, Tim R., & Dhara, Santanu (2013) Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based. Materials Science and Engineering C, 33(3), pp. 1446-1454.
In this study, chitosan-PEO blend, prepared in a 15 M acetic acid, was electrospun into nanofibers (~ 78 nm diameter) with bead free morphology. While investigating physico-chemical parameters of blend solutions, effect of yield stress on chitosan based nanofiber fabrication was clearly evidenced. Architectural stability of nanofiber mat in aqueous medium was achieved by ionotropic cross-linking of chitosan by tripolyphosphate (TPP) ions. The TPP cross-linked nanofiber mat showed swelling up to ~ 300 % in 1h and ~ 40 % degradation during 30 d study period. 3T3 fibroblast cells showed good attachment, proliferation and viability on TPP treated chitosan based nanofiber mats. The results indicate non-toxic nature of TPP cross-linked chitosan based nanofibers and their potential to be explored as a tissue engineering matrix.
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|Item Type:||Journal Article|
|Keywords:||chitosan, electrospinning, tripolyphosphate, yield stress, cytocompatibility|
|Subjects:||Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300) > Chemical Characterisation of Materials (030301)|
|Divisions:||Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
|Copyright Owner:||Copyright 2012 Elsevier B.V.|
|Deposited On:||30 Jul 2013 23:16|
|Last Modified:||01 Aug 2013 06:45|
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