Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based

Dey Sarkar, Soumi, Farrugia, Brooke L., Dargaville, Tim R., & Dhara, Santanu (2013) Physico-chemical/biological properties of tripolyphosphate cross-linked chitosan based. Materials Science and Engineering C, 33(3), pp. 1446-1454.

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In this study, chitosan-PEO blend, prepared in a 15 M acetic acid, was electrospun into nanofibers (~ 78 nm diameter) with bead free morphology. While investigating physico-chemical parameters of blend solutions, effect of yield stress on chitosan based nanofiber fabrication was clearly evidenced. Architectural stability of nanofiber mat in aqueous medium was achieved by ionotropic cross-linking of chitosan by tripolyphosphate (TPP) ions. The TPP cross-linked nanofiber mat showed swelling up to ~ 300 % in 1h and ~ 40 % degradation during 30 d study period. 3T3 fibroblast cells showed good attachment, proliferation and viability on TPP treated chitosan based nanofiber mats. The results indicate non-toxic nature of TPP cross-linked chitosan based nanofibers and their potential to be explored as a tissue engineering matrix.

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9 citations in Web of Science®

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ID Code: 61586
Item Type: Journal Article
Refereed: Yes
Keywords: chitosan, electrospinning, tripolyphosphate, yield stress, cytocompatibility
DOI: 10.1016/j.msec.2012.12.066
ISSN: 0928-4931
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300) > Chemical Characterisation of Materials (030301)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2012 Elsevier B.V.
Deposited On: 30 Jul 2013 23:16
Last Modified: 01 Aug 2013 06:45

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