Poly(2-oxazoline) hydrogels for controlled fibroblast attachment

Farrugia, Brooke L., Kempe, Kristian, Schubert, Ulrich S., Hoogenboom, Richard, & Dargaville, Tim R. (2013) Poly(2-oxazoline) hydrogels for controlled fibroblast attachment. Biomacromolecules, 14(8), pp. 2724-2732.

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Currently there is a lack of choice when selecting synthetic materials with the cell-instructive properties demanded by modern biomaterials. The purpose of this study was to investigate the attachment of cells onto hydrogels prepared from poly(2-oxazoline)s selectively-functionalized with cell adhesion motifs. A water-soluble macromer based on the microwave-assisted cationic ring-opening polymerization of 2-methyl-2-oxazoline and 2-(dec-9-enyl)-2-oxazoline was functionalized with the peptide CRGDSG or controls using thiol-ene photochemistry followed by facile crosslinking in the presence of a dithiol crosslinker. The growth of human fibroblasts on the hydrogel surfaces was dictated by the structure and amount of incorporated peptide. Controls without any peptide showed resistance to cellular attachment. The benignity of the crosslinking conditions was demonstrated by the incorporation of fibroblasts within the hydrogels to produce three-dimensional cell-polymer constructs.

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ID Code: 61888
Item Type: Journal Article
Refereed: Yes
Additional Information: "This article is freely available from the American Chemical Society website 12 months after the publication date. See links to publisher website in this record."
Keywords: poly(2-oxazoline), hydrogel, fibroblast, cell adhesion, thiol-ene, photocure
DOI: 10.1021/bm400518h
ISSN: 1525-7797
Subjects: Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300)
Australian and New Zealand Standard Research Classification > CHEMICAL SCIENCE (030000) > MACROMOLECULAR AND MATERIALS CHEMISTRY (030300) > Synthesis of Materials (030306)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 American Chemical Society
Deposited On: 18 Aug 2013 22:11
Last Modified: 21 Aug 2013 15:44

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