Mass spectrometry-based metabolomics towards understanding of gene functions with a diversity of biological contexts

Lv, Haitao (2013) Mass spectrometry-based metabolomics towards understanding of gene functions with a diversity of biological contexts. Mass Spectrometry Reviews, 32(2), pp. 118-128.

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Currently, mass spectrometry-based metabolomics studies extend beyond conventional chemical categorization and metabolic phenotype analysis to understanding gene function in various biological contexts (e.g., mammalian, plant, and microbial). These novel utilities have led to many innovative discoveries in the following areas: disease pathogenesis, therapeutic pathway or target identification, the biochemistry of animal and plant physiological and pathological activities in response to diverse stimuli, and molecular signatures of host-pathogen interactions during microbial infection. In this review, we critically evaluate the representative applications of mass spectrometry-based metabolomics to better understand gene function in diverse biological contexts, with special emphasis on working principles, study protocols, and possible future development of this technique. Collectively, this review raises awareness within the biomedical community of the scientific value and applicability of mass spectrometry-based metabolomics strategies to better understand gene function, thus advancing this application's utility in a broad range of biological fields

Impact and interest:

15 citations in Scopus
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14 citations in Web of Science®

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ID Code: 62032
Item Type: Journal Article
Refereed: Yes
Keywords: mass spectrometry; metabolomics; gene function;
DOI: 10.1002/mas.21354
ISSN: 1098-2787
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 27 Aug 2013 01:47
Last Modified: 03 Sep 2013 02:12

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