Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs

Schuurman, Wouter, Levett, Peter A., Pot, Michiel W., van Weeren, Paul René, Dhert, Wouter J. A., Hutmacher, Dietmar W., Melchels, Ferry P. W., Klein, Travis J., & Malda, Jos (2013) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs. Macromolecular Bioscience, 13(5), pp. 551-561.

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Abstract

Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.

Impact and interest:

121 citations in Scopus
108 citations in Web of Science®
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ID Code: 62072
Item Type: Journal Article
Refereed: Yes
Keywords: Hydrogels, Gelatin, Cartilage, Photopolymerisation
DOI: 10.1002/mabi.201200471
ISSN: 1616-5187
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 26 Aug 2013 23:41
Last Modified: 19 Jul 2017 05:41

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