Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs

Schuurman, Wouter, Levett, Peter A., Pot, Michiel W., van Weeren, Paul René, Dhert, Wouter J. A., Hutmacher, Dietmar W., Melchels, Ferry P. W., Klein, Travis J., & Malda, Jos (2013) Gelatin-methacrylamide hydrogels as potential biomaterials for fabrication of tissue-engineered cartilage constructs. Macromolecular Bioscience, 13(5), pp. 551-561.

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Gelatin-methacrylamide (gelMA) hydrogels are shown to support chondrocyte viability and differentiation and give wide ranging mechanical properties depending on several cross-linking parameters. Polymer concentration, UV exposure time, and thermal gelation prior to UV exposure allow for control over hydrogel stiffness and swelling properties. GelMA solutions have a low viscosity at 37 °C, which is incompatible with most biofabrication approaches. However, incorporation of hyaluronic acid (HA) and/or co-deposition with thermoplastics allows gelMA to be used in biofabrication processes. These attributes may allow engineered constructs to match the natural functional variations in cartilage mechanical and geometrical properties.

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121 citations in Scopus
108 citations in Web of Science®
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ID Code: 62072
Item Type: Journal Article
Refereed: Yes
Keywords: Hydrogels, Gelatin, Cartilage, Photopolymerisation
DOI: 10.1002/mabi.201200471
ISSN: 1616-5187
Subjects: Australian and New Zealand Standard Research Classification > ENGINEERING (090000) > BIOMEDICAL ENGINEERING (090300) > Biomaterials (090301)
Australian and New Zealand Standard Research Classification > TECHNOLOGY (100000) > MEDICAL BIOTECHNOLOGY (100400) > Regenerative Medicine (incl. Stem Cells and Tissue Engineering) (100404)
Divisions: Current > Institutes > Institute of Health and Biomedical Innovation
Current > QUT Faculties and Divisions > Science & Engineering Faculty
Copyright Owner: Copyright 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
Deposited On: 26 Aug 2013 23:41
Last Modified: 19 Jul 2017 05:41

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