Pharmacokinetic studies of a Chinese triple herbal drug formula

Lv, H., Sun, H., Sun, W., Liu, L., Wang, P., Wang, X., & Cao, H. (2008) Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine, 15(11), pp. 993-1001.

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Abstract

Yin Chen Hao Tang preparation (YCHTP) is a classic traditional Chinese medicine formula, which is commonly used for clinical treatment of hepatological diseases. In this study, a rapid and validated high-performance liquid chromatography (HPLC) method was developed to simultaneously identify 6,7-dimethylesculetin and geniposide in rat plasma. This assay was performed on a Dikma Diamonsil RP(18) column (200 mmx4.6 mm, 5 mum) with acetonitrile-methanol-water (0.1% formic acid) as the mobile phase, showing acceptable linearity, intra- and inter-day precision and accuracy (R.S.D.=5%), and absolute recovery for two analytes (74%); the limits of quantitation were 0.4 and 1.12 mug/ml, and the limits of detection were 0.06 and 0.09 mug/ml for two analytes. The developed method was successfully applied to study the effect of formula compatibility on the pharmacokinetics of 6,7-dimethylesculetin and geniposide in YCHTP when orally administrating an effective human daily dose of YCHTP to rats. We surmise that formula compatibility can significantly influence the pharmacokinetics of YCHTP, and we have elucidated and validated the compatible administration of YCHTP.

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ID Code: 62113
Item Type: Journal Article
Refereed: Yes
Additional Information: Lv, H
Sun, H
Sun, W
Liu, L
Wang, P
Wang, X
Cao, H
Germany
Phytomedicine. 2008 Nov;15(11):993-1001. doi: 10.1016/j.phymed.2008.01.006. Epub 2008 Mar 12.
DOI: 10.1016/j.phymed.2008.01.006
ISSN: 0944-7113
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Sep 2013 02:26
Last Modified: 05 Sep 2013 05:07

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