Pharmacokinetic studies of a Chinese triple herbal drug formula

Lv, H., Sun, H., Sun, W., Liu, L., Wang, P., Wang, X., & Cao, H. (2008) Pharmacokinetic studies of a Chinese triple herbal drug formula. Phytomedicine, 15(11), pp. 993-1001.

View at publisher


Yin Chen Hao Tang preparation (YCHTP) is a classic traditional Chinese medicine formula, which is commonly used for clinical treatment of hepatological diseases. In this study, a rapid and validated high-performance liquid chromatography (HPLC) method was developed to simultaneously identify 6,7-dimethylesculetin and geniposide in rat plasma. This assay was performed on a Dikma Diamonsil RP(18) column (200 mmx4.6 mm, 5 mum) with acetonitrile-methanol-water (0.1% formic acid) as the mobile phase, showing acceptable linearity, intra- and inter-day precision and accuracy (R.S.D.=5%), and absolute recovery for two analytes (74%); the limits of quantitation were 0.4 and 1.12 mug/ml, and the limits of detection were 0.06 and 0.09 mug/ml for two analytes. The developed method was successfully applied to study the effect of formula compatibility on the pharmacokinetics of 6,7-dimethylesculetin and geniposide in YCHTP when orally administrating an effective human daily dose of YCHTP to rats. We surmise that formula compatibility can significantly influence the pharmacokinetics of YCHTP, and we have elucidated and validated the compatible administration of YCHTP.

Impact and interest:

24 citations in Scopus
Search Google Scholar™
17 citations in Web of Science®

Citation counts are sourced monthly from Scopus and Web of Science® citation databases.

These databases contain citations from different subsets of available publications and different time periods and thus the citation count from each is usually different. Some works are not in either database and no count is displayed. Scopus includes citations from articles published in 1996 onwards, and Web of Science® generally from 1980 onwards.

Citations counts from the Google Scholar™ indexing service can be viewed at the linked Google Scholar™ search.

ID Code: 62113
Item Type: Journal Article
Refereed: Yes
Additional Information: Lv, H
Sun, H
Sun, W
Liu, L
Wang, P
Wang, X
Cao, H
Phytomedicine. 2008 Nov;15(11):993-1001. doi: 10.1016/j.phymed.2008.01.006. Epub 2008 Mar 12.
DOI: 10.1016/j.phymed.2008.01.006
ISSN: 0944-7113
Divisions: Current > Schools > School of Biomedical Sciences
Current > QUT Faculties and Divisions > Faculty of Health
Current > Institutes > Institute of Health and Biomedical Innovation
Deposited On: 03 Sep 2013 02:26
Last Modified: 05 Sep 2013 05:07

Export: EndNote | Dublin Core | BibTeX

Repository Staff Only: item control page